somatic gene therapy?

by | Jul 12, 2021 | Uncategorized | 0 comments

You can answer the question posed in this freestyle assignment via a blog post. the rubric is attached.
Have you heard anything about somatic gene therapy? Good things? Bad things? What exactly is somatic gene therapy? Well physicians use a targeting vector (a piece of DNA that helps specify where the nucleotide information should be “delivered” within the genome of the patient) to attempt to add or replace mutated or altered genes with a “normal” version of the gene. This is a fantastic potential therapy for those suffering from a genetic disease that’s defined by a single or closely located mutation. What type of endogenous cellular process/mechanism do these gene therapies in the past have depended upon? What do some modern gene therapy techniques use? (Hint: the most famous is actually an amazing form of adaptive immune system for microbes, and is quite possibly the biggest revolution in biology since the invention of PCR). Look up the stories of Jesse Gelsinger and then look up Ashanti DeSilva, Cindy Kisik and their stories. Finally, examine CRISPR Cas9 (this is the answer to the above hint lol).
Would you elect to undergo gene therapy using CRISPR cas9 (or improved) techniques? What would influence your decision? What about a family member? How would you advise them as to whether they should undergo this therapy or not? Why do you think gene therapy has had a rather tumultuous past? What should we, as the human species, do about potential changes to our human genome going forward? (big, potentially heavy questions and consequences!).

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